| AD | Event |
| 571 | Birth of the Prophet Muhammad |
| 622 | The Hijra: Muhammad leaves Mecca for Medina; the Islamic calendar is dated from this year. |
| 630 | Muhammad conquers Mecca. |
| 632 | Death of the Prophet Muhammad; Abu Bakr becomes the first Caliph. |
| 633-37 | Byzantine Empire defeated by the Arab armies under the Caliph Omar; Syria captured. |
| 636-51 | Arab armies conquer the Persian Empire |
| 638 | Jerusalem surrenders to Caliph Omar. |
| 639-41 | Arab general Amr ibn al-As conquers Egypt. |
| 644 | Caliph Omar assassinated by Persian slave. |
| 661 | Mu'awiya of the Umayyad family becomes Caliph after revolting against Caliph Ali, the Prophet's first cousin and son-in-law. |
| 715 | Arab armies reach France, having swept across Africa to the Atlantic, Spain and Portugal and eastward to Samarkand and India; the Empire is ruled from Damascus. |
| 750 | The Umayyads are overthrown and replaced as Caliphs by the Abbasids, who found a new capital at Baghdad; the dynasty reaches the peak of its power under the fourth Abbasid Caliph, Haroun al-Rashid (786-809) and his son al-Mamun (813-833). |
| 751 | Arabs capture Chinese paper-makers in Central Asia; knowledge of paper making spreads west across Islamic Empire. |
| 788-986 | Independent Idrisid dynasty in Morocco. |
| 800-909 | Independent Aghlabid dynasty in Tunisia. |
| 969 | The Shi'ite descendants of the Prophet's daughter Fatima (the wife of Ali), known as the Fatamids, advance from Tunisia, conquer Egypt, and found Cairo. |
| 970 | Seljuk Turks enter the Caliphate's territories from the east. |
| 1055 | The Seljuks conquer Iraq. |
| 1061 | Normans take Messina and begin conquest of Sicily from Arabs. |
| 1070 | Seljuks occupy Palestine. |
| 1085 | Christians capture Toledo in Spain. |
| 1096-99 | First Crusade results in European Christian capture of Jerusalem (1099) and establishment of four Crusader states in the Middle East. |
| 1144 | Zangi, founder of an independent state based at Mosul, destroys Crusader County of Edessa. |
| 1159 | Zangi's son, Nureddin, captures Damascus and confronts the Crusaders. |
| 1171 | Nureddin's agent, Salah al-Din (Saladin) al-Ayyubi, makes himself ruler of Egypt, ending the Fatimid caliphate and establishing a new dynasty. |
| 1174 | On Nureddin's death, Salah al-Din takes control over Syria. |
| 1187 | Salah al-Din defeats the Crusaders at the Battle of Hittin and retakes Jerusalem. |
| 1250 | Mamluks take power in Egypt during Crusader attack; last Ayyubid ruler in Cairo deposed in 1252. |
| 1258 | Mongols capture Baghdad and end line of Abbasid Caliphs there. |
| 1260 | Mamluks defeat Mongols at Ain Jalut in Palestine. |
| 1291 | Mamluks conquer Acre, the last city held by the Crusaders. |
| 1453 | Ottoman Turks capture Constantinople and bring the Byzantine Empire to an end. |
| 1492 | Christians capture Granada, capital of last of the Muslim states in Spain. |
| 1517 | Ottoman Turks conquer Syria and Egypt and end Mamluk Sultanate. |
| 1520-66 | Reign of Sultan Suleiman "the Magnificent"; Ottoman rule extended along the coast of North Africa; by the end of the 16th century, the Ottoman Empire included present-day Romania, Bulgaria, Greece, Cyprus, Albania, Yugoslavia and parts of Hungary and the Ukraine. |
| 1639 | Ottomans take Iraq (from Persia). |
| 1798 | Napoleon Bonaparte launches an Egyptian expedition and brings Egypt under French rule. |
| 1805 | The Ottomans appoint an Albanian officer, Mohammed Ali, as viceroy or pasha of Egypt; he finally breaks the power of the Mamluks. |
| 1820 | Britain signs treaty with Gulf shaikhs to protect its shipping. |
| 1830 | France begins the conquest of Algeria. |
| 1839 | The British take the port of Aden. |
| 1858 | Maronite peasant uprising in Lebanon is followed by inter-community strife. French intervene in 1860. |
| 1861 | Creation of autonomous Lebanon within the Ottoman Empire. |
| 1881 | France occupies Tunisia. |
| 1882 | British forces occupy Egypt; by 1898, Britain also controls Sudan. |